Interleukin 23 Expression in Pyoderma Gangrenosum and Targeted Therapy With Ustekinumab
نویسندگان
چکیده
منابع مشابه
Interleukin 23 expression in pyoderma gangrenosum and targeted therapy with ustekinumab.
BACKGROUND Interleukin (IL)-23 is involved in the pathogenesis of the chronic inflammatory Crohn disease. Pyoderma gangrenosum (PG) is often associated with and can even be the first manifestation of this disease and has abundant neutrophilic infiltration. Because IL-23 plays a critical role in driving inflammation associated with IL-17 production and especially neutrophil recruitment, we suspe...
متن کاملPyoderma gangrenosum associated with alitretinoin therapy.
PG: pyoderma gangrenosum INTRODUCTION Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition, the etiology of which is poorly understood but is thought to be related to improper neutrophil function and chemotaxis. PG is a clinical diagnosis that requires exclusion of other ulcerative and inflammatory cutaneous disorders. A rare side effect of isotretinoin is the development of ...
متن کاملAdalimumab Therapy for Recalcitrant Pyoderma Gangrenosum
OBJECTIVE To describe a patient with treatment-refractory pyoderma gangrenosum and the outcome of a novel therapeutic approach. METHODS Case report and review of the literature. RESULTS A patient with inflammatory bowel disease developed severe pyoderma gangrenosum while receiving treatment with the chimeric anti-TNF-alpha antibody infliximab. Despite subsequent trials of numerous immunosup...
متن کاملPyoderma gangrenosum.
Pyoderma gangrenosum (PG) is an idiopathic, ulcerative, noninfective chronic inflammatory skin disorder of unknown etiology. It is associated with systemic medical illness in 50% of cases like inflammatory bowel disease, systemic arthritis, haematological diseases and malignancies. Characteristic lesions begin as pustule or vesiculopustule and progresses to an ulcer or deep erosion with violace...
متن کاملSuccessful treatment of refractory pyoderma gangrenosum with ustekinumab only after excision of renal cell carcinoma.
Dear Editors, Pyoderma gangrenosum is a rarely diagnosed neutrophilic disease, which is clinically characterised by very painful ulcers with violaceous, undermined borders (1–3). Even if aetiology and pathogenesis are still not completely understood an association with other systemic diseases, especially inflammatory bowel diseases, was frequently reported. Currently, other relevant comorbiditi...
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 2011
ISSN: 0003-987X
DOI: 10.1001/archdermatol.2011.168